High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group

J Med Chem. 1994 Mar 18;37(6):719-21. doi: 10.1021/jm00032a002.

Authors

G A Showell¹, S Bourrain, J G Neduvelil, S R Fletcher, R Baker, A P Watt, A E Fletcher, S B Freedman, J A Kemp, G R Marshall

Affiliation

¹ Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Center, Harlow Essex, United Kingdom.

PMID: 8145219
DOI: 10.1021/jm00032a002

No abstract available

Publication types

Review

MeSH terms

Animals
Benzodiazepines / chemical synthesis
Benzodiazepines / pharmacology*
Humans
Receptors, Cholecystokinin / antagonists & inhibitors*
Solubility
Stereoisomerism
Structure-Activity Relationship

Substances

Receptors, Cholecystokinin
Benzodiazepines